Exploring the influences of functional connectivity architecture on cortical thickness networks in patients with early psychosis

Kristina M. Holton*, Shi Yu Chan*, Austin J. Brockmeier, Dost Öngür, Mei-Hua Hallk

Exploring the influences of functional connectivity architecture on cortical thickness networks in patients with early psychosis

Kristina M. Holton, Shi Yu Chan, Austin J. Brockmeier, Dost Öngür, Mei-Hua Hallk

Abstract: Cortical thickness and functional connectivity are two parallel approaches that have been widely used to gain insights into psychotic disorders. Significant abnormalities in these modalities, even at the early stage of psychosis, have been shown in the literature. However, few have studied them together or explored the influences of functional connectivity on cortical thickness networks. Prior studies using gyral-based atlases reported that cortical thickness regions susceptible to thickness reductions are strongly interconnected and that brain tissue volume loss in schizophrenia is conditioned by structural and functional connectivity. With data-driven approaches, we assessed: 1) How are cortical thickness networks organized, functionally or structurally? 2) What features drive this organization, and do features vary by diagnosis? 3) What are the relationships between cortical thickness reductions and clinical assessments?

Poster

Abstract: Cortical thickness and functional connectivity are two parallel approaches that have been widely used to gain insights into psychotic disorders. Significant abnormalities in these modalities, even at the early stage of psychosis, have been shown in the literature. However, few have studied them together or explored the influences of functional connectivity on cortical thickness networks. Prior studies using gyral-based atlases reported that cortical thickness regions susceptible to thickness reductions are strongly interconnected and that brain tissue volume loss in schizophrenia is conditioned by structural and functional connectivity. With data-driven approaches, we assessed: 1) How are cortical thickness networks organized, functionally or structurally? 2) What features drive this organization, and do features vary by diagnosis? 3) What are the relationships between cortical thickness reductions and clinical assessments?